Burmese GM2 Gangliosidosis
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Burmese GM2 gangliosidosis is a fatal neurological disease caused by a mutation in the β-subunit of the feline hexoaminadase (HEXB) gene. Affected kittens typically show mild tremors and lack of coordination beginning at 6 to 8 weeks of age.
This is an autosomal recessive mutation, meaning that two copies of the mutant gene are required for the cat to be affected .
Interpretation of results
A Normal The cat does not have the known genetic mutation causing Burmese GM2 gangliosidosis.
A Carrier The cat has one copy of the Burmese GM2 mutation. The cat will not have Burmese GM2 gangliosidosis, but may pass the mutation to their offspring.
An Affected The cat has two copies of the Burmese GM2 mutation. The cat will have Burmese GM2 gangliosidosis.